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Multiplex Innate Cytokine Signal Analyses of Brain Function
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Event Recorded on:
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Thursday, 26 April 2007, 11:00 AM - 12:00 PM
(GMT -07:00) Pacific Time (US & Canada); Tijuana
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Abstract:
Cytokines are powerful signaling molecules that are increasingly recognized for their involvement in normal brain function. Our focus is to decipher how innate cytokine changes associated with increased neural activity, such as that seen from learning, make the brain more resilient to disease. This pursuit is complicated by the complex interactive behavior of innate cytokine signaling, which is highly redundant and pleiotropic in that multiple cytokines can have the same effect and a single cytokine can have variable effects. Our approach is to simultaneously measure key signaling protein changes via multiplex bead-based assays using the Bio-Plex® suspension array system to obtain the data needed to define critical node signaling sites of the innate cytokine signaling network involved in activity-dependent neuroprotection. The application of this experimental strategy to the brain, which is regionally and cellularly heterogeneous, will be discussed.
Presenter Biography:
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Richard P. Kraig
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Dr. Richard Kraig, MD, PhD is an authority on the role of glial cells within the brain, the treatment of migraine headaches, and how the brain protects itself from injury. An active researcher, educator and clinician, Dr. Kraig is the William D. Mabie Professor in Neurosciences at the University of Chicago Hospitals. His laboratory research is focused on examining mechanisms by which the brain naturally protects itself and how physical, mental, and social activities can lessen the impact of neurological disease.
He earned a B.A. in chemistry from Cornell College, a Ph.D. in physiology and biophysics from the University of Iowa and his M.D. from New York University. He was an intern at the University of Chicago and did his residency in neurology at the New York Hospital-Cornell Medical Center where he took his first faculty position before joining Chicago’s faculty in 1988.
The Bio-Plex suspension array system includes fluorescently labeled microspheres and instrumentation licensed to Bio-Rad Laboratories, Inc. by the Luminex Corporation.
*This presentation utilizes internet audio. Please ensure that your computer has audio capabilities before attending.
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